PGP 2008-2009 | PGP 2009-2010 | PGP 2010-2011
SRP 2009-2010 | SRP 2010-2011
DAP: 2008 | 2009 | 2010 | 2011
PPG: 2008 | 2009 | 2010
SRI in OA 2003-2008 | SRI in IJD 2006-2011 | SRI in BIO 2008-2012
SRID: 2007-2008 | 2006-2007 | 2005-2006 | 2004-2005 | 2003-2005 | 2002-2004

Research Grants Awards

Research funding: 2008-2009

PGP 2008-2009

Role of the Notochord during Intervertebral Disc Formation and Maintenance

Cheryle A. Seguin, University of Western Ontario

Abstract:
The intervertebral disc (IVD) is a complex structure essential for spine stabilization and movement composed of three distinct tissues: the nucleus pulposus, annulus fibrosus, and cartilage endplates. Disc degeneration is often initiated at the central nucleus pulposus, making it an intuitive target for regenerative medicine. Bioengineering strategies for IVD replacement are complicated by the recent finding that during embryonic development the nucleus pulposus arises from a lineage distinct from other IVD cells, the notochord. This proposal presents an innovative approach to isolate notochord cells during the major stages of embryonic spine development, to (1) determine what distinguishes these specialized cells from their neighbors and (2) use the purified cells to recreate disc formation in culture.

The role of integrin α1 in chondrocyte signal transduction of osteoarthritis cytokines

Andrea Clark, University of Calgary

Abstract:
This project will investigate the transduction of two osteoarthritis related protein molecules by cartilage cells. Integrin α1, a cartilage cell transmembrane molecule, and its specific role in this transduction will be studied. We will use a genetic mouse model that has had integrin α1 removed from it to study this molecule in its natural cartilage environment. Ion flux and cytoskeletal activation by the chondrocytes in response to the osteoarthritis protein molecules will be measured. Confocal microscopy will be utilized to image these cartilage cell responses in real time and in intact cartilage tissues.

Early Inflammatory Arthritis Help-Seeking Experience 2 (ERAHSE 2)

Anne Townsend, University of British Columbia

Abstract:
Our focus is early inflammatory arthritis (e.g. RA); how people make decisions about treatments, and what influences delays in seeking medical help. We will interview participants three to four times over a year to understand: a) how perceptions of early symptoms change; b) how patients' use of, and communication in, consultations changes; c) what actions people take whilst waiting for the first rheumatologist appointment and beyond; d) how people's decision-making about treatment evolves over time; e) how people navigate a complex medical system; f) how people manage information sources over time.

Effects of Ultrasound on Pain and Function in Osteoarthritis

John Srbely, University of Guelph

Abstract:
This project will investigate the impact of osteoarthritis on the excitability of motoneurones, and the ability for therapeutic ultrasound to reduce motoneurone excitability.

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