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PGP 2008-2009 | PGP 2009-2010 | PGP 2010-2011
SRP 2009-2010 | SRP 2010-2011
DAP: 2008 | 2009 | 2010 | 2011
PPG: 2008 | 2009 | 2010
SRI in OA 2003-2008 | SRI in IJD 2006-2011 | SRI in BIO 2008-2012
SRID: 2007-2008 | 2006-2007 | 2005-2006 | 2004-2005 | 2003-2005 | 2002-2004
Research Grants Awards
Research funding: 2002-2004
CAN is pleased to announce the recipients of the 2002-2004
research grant awards. Click on the links below to go directly
to a research theme, or scroll through the entire list.
Genetics
Analysis of extracellular matrix molecule mutations
in individuals with Ehlers-Danlos syndromes
Principal Investigator: William Cole
Co-Principal Investigator(s): Peter Roughley
Comparative genomics of pufferfish metallo proteinase
gene promoters and functional analysis in transgenic frogs
Principal Investigator: Frank Jirik
Genetic studies in rheumatoid arthritis
Principal Investigator: Kathy Siminovitch
Co-Principal Investigator(s): Frank Jirik, Tom Hudson
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Inflammation
Interleukin-1 signaling through focal adhesions
Principal Investigator: Chris McCulloch
Co-Principal Investigator(s): Jaro Sodek, Chris Overall,
Tony Cruz
Partner: Transition Therapeutics Inc.
Intracellular peptides as inhibitors of neutrophil
recruitment and responses to interleukin-8
Principal Investigator: Paul Naccache
Anti-inflammatory chemokine antagonists for treating
arthritis
Principal Investigator: Chris Overall
Co-Principal Investigator(s): Chris McCulloch
The role of DDR2-receptor tyrosine kinase in rheumatoid
arthritis
Principal Investigator: Rob Rottapel
Co-Principal Investigator(s): Tony Pawson
Towards the development of new anti-cytokine pharmacotherapy
Principal Investigator: John Di Battista
Lipid mediators of inflammation: characterization
of the anti-inflammatory actions of prostaglandin E2 and
evaluation of metabolic stable PGE2 mimetics in animal models
of inflammation of arthritis
Principal Investigator: Pierre Borgeat
Co-Principal Investigator(s): John Di Battista, Walid Mourad, Patrice Poubelle,
Marc Pouliot
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Cellular
and molecular biology of joint tissues
Coordinated signalling by growth factors in cartilage
and bone development and regeneration
Principal Investigator: Janet Henderson
Co-Principal Investigator(s): David Goltzman, David Hill,
Andrew Karaplis, Frank Beier
Partners: Ciblex, Skyscan
Development of bone and cartilage; the role of
the nuclear steroid orphan estrogen related receptor
Principal Investigator: Jane Aubin
Co-Principal Investigator(s): Frank Beier, Suzanne Bernier,
Michael Underhill
Partners: Milestone Medica, Allergan
Metalloproteases and cartilage destruction in mouse
models of arthritis
Principal Investigator: John Mort
Co-Principal Investigator(s): Rama Khokha
Recombinant peptides for the promotion and inhibition
of mineral formation
Principal Investigator: Harvey Goldberg
Co-Principal Investigator(s): Graeme Hunter, Marc Grynpas,
Marc McKee, Jaro Sodek
Role of osteopontin in inflammatory arthritis
Principal Investigator: Jaro Sodek
Co-Principal Investigator(s): Marc Grynpas, Marc McKee,
Harvey Goldberg, Graeme Hunter
Partner: Immundiagnostic AG
Overexpression of the osteoclast-specific V-ATPase
subunit, "a3", in RAW264.7 cells: a potential
screen for antiresorptive agents to prevent bone loss in
inflammatory arthritis
Principal Investigator: Morris Manolson
Co-Principal Investigator(s): Johan Heersche, Jeff Dixon,
Stephen Sims
Roles of matrix metalloproteinases and their inhibitors
in joints
Principal Investigator: Muhammad Zafarullah
Partner: Wyeth Ayerst Canada
Osteoclastic resorption in inflammatory arthritis:
regulation of osteoclasts and angiogenesis by the alpha-v
beta-3 integrin blocker Vitaxin
Principal Investigator: Jeff Dixon
Co-Principal Investigator(s): Artur de Brum-Fernandes, Hani
El-Gabalawy, Johan Heersche, Stephen Sims
Partner: Medimmune
Searching for articular cartilage stem cells
Principal Investigator: John Matyas
Co-Principal Investigator(s): Jane Aubin
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Bioengineering
for joint reconstruction
Development of an in situ gelling polymer delivery
vehicle for cell-assisted repair of cartilage
Principal Investigator: Mike Buschmann
Co-Principal Investigator(s): Marc McKee, Aboulfazl Shirazi-Adl,
Mark Hurtig
Partner: Biosyntech
Formation of tissue engineered implants for repair
of osteochondral defects
Principal Investigator: Rita Kandel
Co-Principal Investigator(s): Marc Grynpas, Bob Pilliar
Assessment of meniscus healing in vivo
Principal Investigator: Nigel Shrive
Co-Principal Investigator(s): David Hart, Cy Frank, Rita Kandel, Bob Pilliar,
Marc Grynpas, Mike Buschmann
Partner: Biosyntech
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Diagnostics
& therapeutics
Clinical surrogates for cartilage degradation in
arthritis
Principal Investigator: Robin Poole
Co-Principal Investigator(s): Sheila Laverty, Neil Hartman
Partners: Amgen, Wyeth Ayerst, HDM Diagnostics and Imaging
Inc., ClinTrials Bioresearch
Validation of a rabbit model of osteoarthritis
using non-invasive imaging techniques
Principal Investigator: David Holdsworth
Co-Principal Investigator(s): Stuart Foster, Colin Webber,
Sheila Laverty
Partner: Enhanced Vision Systems Corp.
Development of an intra-articular delivery system
Principal Investigator: Helen Burt
Co-Principal Investigator(s): Tony Cruz
Partner: Angiotech
Design and monitoring of low-wear bearings for
total joint replacement
Principal Investigator: Tim Bryant
Co-Principal Investigator(s): Dennis Bobyn, John Medley
Computer-assisted joint replacement surgery
Principal Investigator: James Johnson
Co-Principal Investigator(s): Graham King, David Chess
Development of an intra-operative measurement system
for total knee arthroplasty
Principal Investigator: David Chess
Co-Principal Investigator(s): James Johnson, Graham King
Establishment of a bank of synovial fluids and
paired sera from arthritic patients for the evaluation of
new methods facilitating the diagnosis and the monitoring
of progression and therapy of arthritis
Principal Investigator: Yves St-Pierre
Co-Principal Investigator(s): Gilles Boire, Artur de Brum-Fernandes, Robin Poole,
Henri Ménard
Partner: Biophage Pharma
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Methodologies
& outcomes
Development of a cost saving and efficient clinical
data management tool
Principal Investigator: Rolf Sebaldt
Assessing the quality of care of rheumatoid arthritis
at a population level
Principal Investigator: Diane Lacaille
Multilevel adaptive assessment of health related
quality of life: integration of item response theory and
preference-based measurement
Principal Investigator: Jacek Kopec
Characterizing the clinical, quality of life, and
economic outcomes in juvenile idiopathic arthritis
Principal Investigator: Peter Malleson
Co-Principal Investigator(s): Ann Clarke, Patricia Dobkin,
Ciaran Duffy, Debbie Feldman
Arthritis disability and participation in employment:
analysis
Principal Investigator: Monique Gignac
Co-Principal Investigator(s): Aslam Anis
The sensitivity to change and responsiveness of
indirect utility measures and a disease-specific measure
in patients with rheumatoid arthritis
Principal Investigator: Aslam Anis
Co-Principal Investigator(s): John Esdaile
Cost-effectiveness of anakinra (a new interleukin-1
blocker) compared to standard therapy and infliximab plus
methotrexate for the treatment of rheumatoid arthritis
Principal Investigator: Aslam Anis
Co-Principal Investigator(s): John Esdaile
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Special
initiatives
Course of osteoarthritis (OA): a multidisciplinary
programmatic proposal to measure the trajectory of OA
Principal Investigator: Elizabeth Badley
Co-Principal Investigator(s): Gillian Hawker, Michal Abrahamowicz, Monique Gignac,
Paul Fortin, John Esdaile
Partner: HDM Diagnostics and Imaging Inc.
For more information, contact:
Johnathan Riley
Managing Director
Phone: 416-586-3167
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